Year 2023, twenty years after the start of a worldwide plague that infected the population with a mutated fungus, turning people into cannibalistic creatures, the smuggler Joel is tasked with escorting the teenager Ellie through a post-apocalyptic world where nothing will be easy for the travelers. Joel is still tormented by the memory of his only daughter. Ellie carries something that could change the fate of humanity. Will the two of them manage to survive?